rsjРоссийский хирургический журналRussian surgical journal3034-72703033-5604Фонд Алмазова10.18705/3034-7270-2025-1-2-112-117rsj-30Research ArticleМИНИМАЛЬНО ИНВАЗИВНАЯ ХИРУРГИЯМИНИМАЛЬНО ИНВАЗИВНАЯ ХИРУРГИЯБиопсия сторожевого лимфатического узла при опухолях головы и шеи: современное состояние с позиций доказательной медицины. Роль радиоизотопной диагностики (обзор литературы)Sentinel lymph node biopsy in head and neck tumors: current status from the standpoint of evidence-based medicine. The role of radioisotope diagnostics (literature review)https://orcid.org/0009-0008-1051-882XДмитриевС. П.DmitrievS. P.

Дмитриев Сергей Павлович – заведующий 9-м онкологическим отделением опухолей головы и шеи

Нижний Новгород

Dmitriev Sergey P. – Head of the 9th Oncology Department of Head and Neck Tumors

Nizhny Novgorod

sergei-fcsm@yandex.ruhttps://orcid.org/0000-0001-7335-895XТер-ОванесовМ. Д.Ter-OvanesovM. D.

Тер-Ованесов Михаил Дмитриевич – д-р мед. наук, профессор, заместитель главного врача

Нижний Новгород

Ter-Ovanesov Mikhail D. – Doctor of Medical Sciences, Professor, Deputy Chief Physician

Nizhny Novgorod

termd@yandex.ruhttps://orcid.org/0009-0006-9973-9383КазаковА. А.KazakovA. A.

Казаков Алексей Александрович – руководитель 2-го стационара

Нижний Новгород

Kazakov Aleksey A. – Head of the 2nd Inpatient Department

Nizhny Novgorod

ka278@mail.ruhttps://orcid.org/0009-0009-0603-3915БуроваТ. В.BurovaT. V.

Бурова Татьяна Валерьевна – заведующая отделением радионуклидной диагностики

Нижний Новгород

Burova Tatyana V. – Head of the Radionuclide Diagnostics Department

Nizhny Novgorod

burovatv2013@yandex.ruhttps://orcid.org/0009-0009-8531-612XАлексинаВ. И.AleksinaV. I.

Алексина Валерия Игоревна – врач-онколог 9-го онкологического отделения опухолей головы и шеи

Нижний Новгород

Aleksina Valeria I. – Oncologist, Department of Oncology of Head and Neck Tumors

Nizhny Novgorod

leraf243456@gmail.comhttps://orcid.org/0009-0004-3761-2286МасловН. М.MaslovN. M.

Маслов Никита Максимович – врач-онколог 9-го онкологического отделения опухолей головы и шеи

Нижний Новгород

Maslov Nikita M. – Oncologist, Department of Oncology of Head and Neck Tumors

Nizhny Novgorod

nikita.maslov.1999@mail.ruНИИКО «Нижегородский областной клинический онкологический диспансер»РоссияNizhny Novgorod Regional Clinical Oncological DispensaryRussian Federation20250909202512112117Copyright © Дмитриев С.П., Тер-Ованесов М.Д., Казаков А.А., Бурова Т.В., Алексина В.И., Маслов Н.М., 20252025Дмитриев С.П., Тер-Ованесов М.Д., Казаков А.А., Бурова Т.В., Алексина В.И., Маслов Н.М.Dmitriev S.P., Ter-Ovanesov M.D., Kazakov A.A., Burova T.V., Aleksina V.I., Maslov N.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://rsj.elpub.ru/jour/article/view/30

Представлен обзор публикаций, посвященных клинической эффективности, безопасности и технологическим аспектам радионуклидной биопсии сторожевого лимфатического узла у больных с ранними формами плоскоклеточного рака головы и шеи. Проанализированы результаты четырех рандомизированных исследований и крупного мета-анализа 2022 г., данные систематических обзоров 2023–2024 гг., проспективных когорт из Европы и Азии, а также серии наблюдений, выполненные с использованием наноколлоида 99mTc альбумина человеческого («Нанотоп»). Отдельным разделом рассмотрены физико-химические и клинические преимущества радионуклидного метода по сравнению с альтернативными трейсерами.

The article provides an overview of recent publications on the clinical efficacy, safety, and technological aspects of radionuclide sentinel lymph node biopsy in patients with early forms of squamous cell carcinoma of the head and neck. The results of four randomized trials and a large meta-analysis in 2022, data from systematic reviews in 2023–2024, prospective cohorts from Europe and Asia, as well as a series of observations performed using the 99mTc human albumin nanocolloid ("Nanotope") were analyzed. A separate section discusses the physico-chemical and clinical advantages of the radionuclide method in comparison with alternative tracers.

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The authors declare that there are no conflicts of interest present.