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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">rsj</journal-id><journal-title-group><journal-title xml:lang="ru">Российский хирургический журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Russian surgical journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">3034-7270</issn><issn pub-type="epub">3033-5604</issn><publisher><publisher-name>Фонд Алмазова</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.18705/3034-7270-2025-1-3-47-56</article-id><article-id custom-type="edn" pub-id-type="custom">OQLBVW</article-id><article-id custom-type="elpub" pub-id-type="custom">rsj-61</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Особенности патогенеза остеоартрита тазобедренного и коленного суставов при коморбидной патологии (обзор литературы)</article-title><trans-title-group xml:lang="en"><trans-title>Features of the pathogenesis of osteoarthritis of the hip and knee joints in comorbid pathology (literature review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4165-4599</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Уразовская</surname><given-names>И. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Urazovskaya</surname><given-names>I. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Уразовская Ирина Леонидовна – канд. мед. наук, ассистент.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Urazovskaya Irina L. – Candidate of Medical Sciences, Assistant.</p><p>St. Petersburg</p></bio><email xlink:type="simple">doc.urazovskaya@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6681-2858</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мироевский</surname><given-names>Ф. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Miroevskiy</surname><given-names>F. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мироевский Филипп Владиславович – канд. мед. наук, доцент кафедры общей хирургии.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Miroevskiy Filipp V. – Candidate of Medical Sciences, Associate Professor of the Department of General Surgery.</p><p>St. Petersburg</p></bio><email xlink:type="simple">traumafil@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2660-9469</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Остапченко</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ostapchenko</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Остапченко Андрей Александрович – канд. мед. наук, доцент кафедры общей хирургии.</p><p>Санкт-Петербург</p></bio><bio xml:lang="en"><p>Ostapchenko Andrey A. – Candidate of Medical Sciences, Associate Professor of the Department of General Surgery.</p><p>St. Petersburg</p></bio><email xlink:type="simple">aostap@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1799-641X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мансуров</surname><given-names>Д. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Mansurov</surname><given-names>D. Sh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мансуров Джалолидин Шамсидинович – канд. мед. наук, заведующий кафедры лучевой диагностики и терапии.</p><p>Самарканд</p></bio><bio xml:lang="en"><p>Mansurov Jalolidin S. – Candidate of Medical Sciences, Head of the Department of Radiation Diagnostics and Therapy.</p><p>Samarkand</p></bio><email xlink:type="simple">jalolmedic511@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Северо-Западный государственный медицинский университет им. И.И. Мечникова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.I. Mechnikov Northwestern State Medical University of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр им. В.А. Алмазова Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Almazov National Medical Research Center of the Ministry of Health of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Самаркандский государственный медицинский университет</institution><country>Узбекистан</country></aff><aff xml:lang="en"><institution>Samarkand State Medical University</institution><country>Uzbekistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>08</day><month>11</month><year>2025</year></pub-date><volume>1</volume><issue>3</issue><fpage>47</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Уразовская И.Л., Мироевский Ф.В., Остапченко А.А., Мансуров Д.Ш., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Уразовская И.Л., Мироевский Ф.В., Остапченко А.А., Мансуров Д.Ш.</copyright-holder><copyright-holder xml:lang="en">Urazovskaya I.L., Miroevskiy F.V., Ostapchenko A.A., Mansurov D.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://rsj.elpub.ru/jour/article/view/61">https://rsj.elpub.ru/jour/article/view/61</self-uri><abstract><p>Ежегодно в России регистрируется около 600 тыс. новых случаев с установленным диагнозом остеоартрита тазобедренного или коленного суставов. Общее количество пациентов может достигать около 15 млн. При этом наблюдается тенденция к росту заболеваемости с 32,2 до 35,7 случаев на каждую тысячу населения. Проводился поиск данных литературы в открытых электронных базах научной литературы PubMed и еLIBRARY по ключевым словам и словосочетаниям. За последние 20 лет определяется внушительный рост числа пациентов с данным заболеванием – на 260 %. При исследовании возрастной структуры отмечаются значимые отличия в показателях заболеваемости. В настоящий момент при разговоре об остеоартрите пристальное внимание уделяется мультифакторной природе заболевания. Механическое воздействие играет решающую роль в запуске патологического процесса. С другой стороны, не менее важным в развитии заболевания следует считать метаболический синдром, его наличие может потенцировать риск развития остеоартрита более чем в два раза. Таким образом, распространенность остеоартрита и неуклонный рост заболеваемости, а также усугубление его течения при наличии сопутствующих заболеваний приводят к тому, что необходим особый подход к больным с коморбидным состоянием и дальнейшее их изучение.</p></abstract><trans-abstract xml:lang="en"><p>About 600 thousand new cases with an established diagnosis of osteoarthritis are registered annually in Russia. The total number of patients can reach about 15 million. At the same time, there is a tendency for the incidence to increase from 32.2 to 35.7 cases per thousand population. Literature data was searched in the open electronic databases of scientific literature PubMed and Library. The search was carried out by keywords and phrases. Over the past 20 years, there has been an impressive increase in the number of patients with this disease – by 260 %. When examining the age structure, it should be noted that there are quite significant differences in morbidity rates. Currently, when talking about osteoarthritis, close attention is paid to the multifactorial nature of the disease. Undoubtedly, mechanical action plays a crucial role in triggering the pathological process. On the other hand, the metabolic syndrome should be considered equally important in the development of the disease, its presence can potentiate the risk of developing osteoarthritis by more than two times. Thus, the prevalence of osteoarthritis and the steady increase in morbidity, as well as the aggravation of its course in the presence of concomitant diseases, lead to the need for a special approach to patients with comorbid conditions and their further study.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>остеоартрит тазобедренного и коленного суставов</kwd><kwd>сопутствующая патология</kwd><kwd>коморбидность</kwd><kwd>патогенез</kwd><kwd>метаболический синдром</kwd></kwd-group><kwd-group xml:lang="en"><kwd>osteoarthritis of the hip and knee joints</kwd><kwd>concomitant pathology</kwd><kwd>comorbidity</kwd><kwd>pathogenesis</kwd><kwd>metabolic syndrome</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Авторы заявляют об отсутствии внешнего финансирования при проведении исследования</funding-statement><funding-statement xml:lang="en">This study was not supported by any external sources of funding</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Денисов Л.Н., Бугрова О.В., Дыдыкина И.С. и др. 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