Preview

Russian surgical journal

Advanced search

Revolution in herniology: Forecast for the next 25 years

https://doi.org/10.18705/3034-7270-2025-1-2-42-47

Abstract

In the next 25 years, medicine, and surgery in particular, will undergo revolutionary changes, mainly due to a combination of biotechnology, artificial intelligence and the emergence of new materials. With a high degree of probability, the focus of surgical science will be on biocompatible materials, personalization of treatment using artificial intelligence algorithms, as well as the development of fully automated robotic systems. Based on existing experimental and preclinical studies, it is possible to get an idea of current trends that can be guessed in existing and emerging technologies, which allows us to describe the outlines of the near future with a high degree of probability and, based on a detailed analysis, describe the expected, and possibly desired, technologies.

About the Author

B. V. Sigua
Almazov National Medical Research Centre of the Ministry of Health of Russian Federation
Russian Federation

Sigua Badri V. – Doctor of Medical Sciences, Professor, Head of the Department of General Surgery

St. Petersburg



References

1. Bassini E. Nuovo metodo operativo per la cura dell’ernia inguinale. Padua: Prosperini, 1889.

2. Usher F.C. A new plastic prosthesis for repairing tissue defects of the chest and abdominal wall. Am J Surg. 1959;97(5):629–33. DOI: 10.1016/0002-9610(59)90256-9.

3. Irving L. Lichtenstein, Alex G. Shulman Ambulatory outpatient hernia surgery. Including a new concept, introducing tension-free repair. International Surgery (Int Surg). 1986;71(1):1 –4.

4. Qiao J., Jiang Z., Yang Y., et al. Study of a new biodegradable hernia patch to repair abdominal wall defect in rats. Carbohydr Polym. 2017;15(172):255–264. DOI: 10.1016/j.carbpol.2017.05.035.

5. Chen J., Hong G., Guo N., Liu T. Hernia repair patch: recent advances in material design and application. Chinese Journal of Tissue Engineering Research. 2025;29(16):3494–3502.

6. Liu Z., Liu X, Bao L., et al. The evaluation of functional small intestinal submucosa for abdominal wall defect repair in a rat model: Potent effect of sequential release of VEGF and TGF-β1 on host integration. Biomaterials. 2021;276:120999. DOI: 10.1016/j.biomaterials.2021.120999.

7. Zhang N., Huang Y., Wei P., et al. Killing two birds with one stone: A therapeutic copper-loaded bio-patch promoted abdominal wall repair via VEGF pathway. Mater Today Bio. 2023;22:100785. DOI: 10.1016/j.mtbio.2023.100785.

8. Melissa T.B., Pallavi C., Lizhong D., Willy H. The roles of TGF-β and VEGF pathways in the suppression of antitumor immunity in melanoma and other solid tumors. Pharmacol Ther. 2022;240:108211. DOI: 10.1016/j.pharmthera.2022.108211.

9. Ziqin D., Tao F., Chu X., et al. TGF-β signaling in health, disease and therapeutics. Signal Transduct Target Ther. 2024;9:61. DOI: 10.1038/s41392-024-01764-w.

10. Paola A. Guerrero and Joseph H. McCarty TGF-β Activation and Signaling in Angiogenesis. Physiologic and Pathologic Angiogenesis – Signaling Mechanisms and Targeted Therapy. 2017. DOI: 10.5772/66405.

11. Savari R., Shafiei M., Galehdari H., Kesmati M. Expression of VEGF and TGF-β Genes in Skin Wound Healing Process Induced Using Phenytoin in Male Rats. Jundishapur Journal of Health Sciences. DOI: 10.5812/jjhs.86041.

12. Ferrari G., Cook B.D., Terushkin V., et al. Transforming growth factor-beta 1 (TGF-β1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis. J Cell Physiol. 2009;219(2):449–458. DOI: 10.1002/jcp.21706.

13. Bonfiglio V., Platania C.B.M., Lazzara F., Conti F. TGF-β Serum Levels in Diabetic Retinopathy Patients and the Role of Anti-VEGF Therapy. Int. J. Mol. Sci. 2020;21(24):9558. DOI: 10.3390/ijms21249558.

14. Kallyanashis P., Saeedeh D, O'Connell C.D., et al. 3D Printed Mesh Geometry Modulates Immune Response and Interface Biology in Mouse and Sheep Model: Implications for Pelvic Floor Surgery. Adv Sci (Weinh). 2025;12(11):e2405004. DOI: 10.1002/advs.202405004.

15. Omelko N.A., Khalimov R.I. Composite matrices for use in traumatology and regenerative medicine. Scientific review. Medical sciences. 2022;6:89–94. DOI: 10.17513/srms.1309. (In Russ.)

16. Saiding Q., Chen Y., Wang J., et al. Abdominal wall hernia repair: from prosthetic meshes to smart materials. Mater Today Bio. 2023;21:100691. DOI: 10.1016/j.mtbio.2023.100691.

17. Clarke T. Fibrin glue for intraperitoneal laparoscopic mesh fixation: comparative study in swine model. Surg. Endosc. 2011;25:737–748.

18. Pandey N., Soto-Garcia L.F., J. Liao, et al. Mussel-Inspired Bioadhesives in Healthcare: Design Parameters, Current Trends, and Future Perspectives. Biomater Sci. 2020;8(5):1240–1255. DOI: 10.1039/c9bm01848d.

19. Xiang G.-M., Zhang X.-L., Xu C.-J., et al. The collagen type I alpha 1 chain gene is an alternative safe harbor locus in the porcine genome. Journal of Integrative Agriculture. 2023;22(1):202–213. DOI: 10.1016/j.jia.2022.08.105.

20. Cao Y., Li L., Ren X., et al. CRISPR/Cas9 correction of a dominant cis-double-variant in COL1A1 isolated from a patient with osteogenesis imperfecta increases the osteogenic capacity of induced pluripotent stem cells. J Bone Miner Res. 2023;38(5):719–732. DOI: 10.1002/jbmr.4783.

21. Huang Y., Dong J., Feng L., Li P. Effects of endogenous nestin overexpression on proliferation, migration and MAPK signal transduction pathway in NIH3T3 cells. Journal of Third Military Medical University. 2020;42(2):125–132.

22. Kamalov A.A., Okhobotov D.A. Stem cells and their use in modern clinical practice. Urology. 2012;(5):105–114. (In Russ.)

23. Ma Q., Liao J., Cai X. Different Sources of Stem Cells and their Application in Cartilage Tissue Engineering. Curr Stem Cell Res Ther. 2018;13(7):568–575. DOI: 10.2174/1574888X13666180122151909.

24. Wang Z., Ren L., Li Z., et al. Impact of Different Cell Types on the Osteogenic Differentiation Process of Mesenchymal Stem Cells. Stem Cells Int. 2025:5551222. DOI: 10.1155/sci/5551222.

25. Yamaguchi N., Horio E., Sonoda J., et al. Immortalization of Mesenchymal Stem Cells for Application in Regenerative Medicine and Their Potential Risks of Tumorigenesis. Int J Mol Sci. 2024;25(24):13562. DOI: 10.3390/ijms252413562.

26. Zulkifli D., Manan H. A., Yahya N., Hamid H. A. The Applications of High-Intensity Focused Ultrasound (HIFU) Ablative Therapy in the Treatment of Primary Breast Cancer: A Systematic Review. Diagnostics. 2023;13(15):2595. DOI: 10.3390/diagnostics13152595.

27. Bachu V.S., Kedda J., Suk I., et al. High-Intensity Focused Ultrasound: A Review of Mechanisms and Clinical Applications. Ann Biomed Eng. 2021;49(9):1975–1991. DOI: 10.1007/s10439-021-02833-9.

28. Kun G., Wan M. Effects of fascia lata on HIFU lesioning in vitro. Ultrasound Med Biol. 2004;30(7):991–8. DOI: 10.1016/j.ultrasmedbio.2004.05.004.

29. Zhou N., Zhang C.‐T., Lv H.‐Y., et al. Concordance Study Between IBM Watson for Oncology and Clinical Practice for Patients with Cancer in China. Oncologist. 2018;24(6):812–819. DOI: 10.1634/theoncologist.2018-0255.

30. Yuda E., Kaneko I., Hirahara D. Machine-Learning Insights from the Framingham Heart Study: Enhancing Cardiovascular Risk Prediction and Monitoring. Appl. Sci. 2025;15(15):8671. DOI: 10.3390/app15158671.

31. Woong J., Kim B., Chen J.-T., et al. SRT-H: A hierarchical framework for autonomous surgery via language-conditioned imitation learning. Sci Robot. 2025;10(104):eadt5254. DOI: 10.1126/scirobotics.adt5254.

32. Chegini S., Edwards E., McGurk M., et al. Systematic review of techniques used to validate the registration of augmented-reality images using a head-mounted device to navigate surgery. Br J Oral Maxillofac Surg. 2023;61(1):19–27. DOI: 10.1016/j.bjoms.2022.08.007.


Review

For citations:


Sigua B.V. Revolution in herniology: Forecast for the next 25 years. Russian surgical journal. 2025;1(2):42-47. (In Russ.) https://doi.org/10.18705/3034-7270-2025-1-2-42-47

Views: 17


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 3034-7270 (Print)
ISSN 3033-5604 (Online)