Features of the pathogenesis of osteoarthritis of the hip and knee joints in comorbid pathology (literature review)
https://doi.org/10.18705/3034-7270-2025-1-3-47-56
EDN: OQLBVW
Abstract
About 600 thousand new cases with an established diagnosis of osteoarthritis are registered annually in Russia. The total number of patients can reach about 15 million. At the same time, there is a tendency for the incidence to increase from 32.2 to 35.7 cases per thousand population. Literature data was searched in the open electronic databases of scientific literature PubMed and Library. The search was carried out by keywords and phrases. Over the past 20 years, there has been an impressive increase in the number of patients with this disease – by 260 %. When examining the age structure, it should be noted that there are quite significant differences in morbidity rates. Currently, when talking about osteoarthritis, close attention is paid to the multifactorial nature of the disease. Undoubtedly, mechanical action plays a crucial role in triggering the pathological process. On the other hand, the metabolic syndrome should be considered equally important in the development of the disease, its presence can potentiate the risk of developing osteoarthritis by more than two times. Thus, the prevalence of osteoarthritis and the steady increase in morbidity, as well as the aggravation of its course in the presence of concomitant diseases, lead to the need for a special approach to patients with comorbid conditions and their further study.
Keywords
osteoarthritis of the hip and knee joints,
concomitant pathology,
comorbidity,
pathogenesis,
metabolic syndrome
Supporting agencies: This study was not supported by any external sources of funding
About the Authors
I. L. Urazovskaya
I.I. Mechnikov Northwestern State Medical University of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Urazovskaya Irina L. – Candidate of Medical Sciences, Assistant.
St. Petersburg
F. V. Miroevskiy
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Miroevskiy Filipp V. – Candidate of Medical Sciences, Associate Professor of the Department of General Surgery.
St. Petersburg
A. A. Ostapchenko
Almazov National Medical Research Center of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Ostapchenko Andrey A. – Candidate of Medical Sciences, Associate Professor of the Department of General Surgery.
St. Petersburg
D. Sh. Mansurov
Samarkand State Medical University
Uzbekistan
Uzbekistan
Mansurov Jalolidin S. – Candidate of Medical Sciences, Head of the Department of Radiation Diagnostics and Therapy.
Samarkand
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For citations:
Urazovskaya I.L., Miroevskiy F.V., Ostapchenko A.A., Mansurov D.Sh. Features of the pathogenesis of osteoarthritis of the hip and knee joints in comorbid pathology (literature review). Russian surgical journal. 2025;1(3):47-56. (In Russ.) https://doi.org/10.18705/3034-7270-2025-1-3-47-56. EDN: OQLBVW
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